Detectable mutations precede late myeloid neoplasia in aplastic anemia
نویسندگان
چکیده
منابع مشابه
MYELOID NEOPLASIA SNP array–based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes
In aplastic anemia (AA), contraction of the stem cell pool may result in oligoclonality, while in myelodysplastic syndromes (MDS) a single hematopoietic clone often characterized by chromosomal aberrations expands and outcompetes normal stem cells. We analyzed patients with AA (N 93) and hypocellular MDS (hMDS, N 24) using single nucleotide polymorphism arrays (SNP-A) complementing routine cyto...
متن کاملALLOGENIC BONE MARROW TRANSPLANTATION IN APLASTIC ANEMIA
Eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (BMT) from HLA-matched siblings during the period of 1990 to 1996. The conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. Antilymphocyte globulin (ALG) and cyclosporine were used for rejection and acute GVHD prophylaxis, respe...
متن کاملAcute myeloid leukemia after intensive immunosuppressive therapy in aplastic anemia.
A 10-year-old boy was admitted with complaints of fever, pallor, fatigue and skin bleeds of 10 days duration and diagnosed as very severe aplastic anemia. He was given intensive immunosuppressive therapy but showed no response to therapy. He later evolved into acute myeloid leukemia. The occurrence of AML is reviewed and possible pathogenesis is discussed.
متن کاملPerforin gene mutations in patients with acquired aplastic anemia.
Perforin is a cytolytic protein expressed mainly in activated cytotoxic lymphocytes and natural killer cells. Inherited perforin mutations account for 20% to 40% of familial hemophagocytic lymphohistiocytosis, a fatal disease of early childhood characterized by the absence of functional perforin. Aplastic anemia, the paradigm of immune-mediated bone marrow failure syndromes, is characterized by...
متن کاملSomatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
BACKGROUND In patients with acquired aplastic anemia, destruction of hematopoietic cells by the immune system leads to pancytopenia. Patients have a response to immunosuppressive therapy, but myelodysplastic syndromes and acute myeloid leukemia develop in about 15% of the patients, usually many months to years after the diagnosis of aplastic anemia. METHODS We performed next-generation sequen...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2020
ISSN: 1592-8721,0390-6078
DOI: 10.3324/haematol.2020.263046